Welcome

The Dutch Huntington’s Disease Symposium provides a forum for research into the care and cure of Huntington’s Disease. The meeting will include topics such as molecular mechanisms, biomarkers, therapies and care in Huntington’s Disease, with a special focus on biomarkers.

Biomarkers in Huntington’s Disease

The diagnosis of Huntington’s Disease is based on clinical signs and symptoms. However, we know that many years before the clinical diagnosis is made, patients already show cognitive, behavioural and brain MRI changes. Detecting such changes is of huge importance related to future disease modifying treatments. Biomarkers can help monitor the disease development before clinical signs and symptoms arise. Biomarkers can be detected in fluids such as cerebrospinal fluid, blood or tears. They can also be detected by using imaging such as brain MRI or retinal imaging.

Focus on research on biomarkers in Huntington’s Disease

The 2nd Dutch Huntington’s Disease Symposium focus on topics such as molecular mechanisms, biomarkers, therapies and care in Huntington’s Disease, with a special focus on biomarkers.
  • What biomarkers may be useful in the search for the ultimate treatment?
  • At what age do we need to start tracing these biomarkers?
  • What new research challenges and initiatives have come to the forefront?

The Dutch Huntington’s Disease symposium

We hope that you will enjoy our very topical Huntington’s Disease symposium, take this opportunity to get to know your colleagues’ research better, and be inspired by our collective scientific work.

Dr. Mayke Oosterloo
Head of Huntington’s Disease Expertise Center Maastricht UMC+ 

Programme Friday November 5, 2021

Joint meeting DHDRN (Dutch Huntington Disease Research Network) and HKNN (Huntington KennisNet Nederland)
10.00-10.10 | Welcome
Mayke Oosterloo; Neurologist, Maastricht UMC+

10.10-10.15 | Introduction
Chair: Eric Reits, Professor, Amsterdam University Medical Center, (AUMC) Department Medical Biology

10.15-10.45 | Plenary Session
• MRI as a source for biomarker research >

David Linden, Professor Translational Neuroscience and Scientific Director of the School for Mental Health and Neuroscience (MHeNs) Maastricht University
• Huntington Partner in Balance: online self-management for partners/caregivers of persons with Huntington Disease (HD) >
Annelien Duits, Clinical neuropsychologist at the Department of Psychiatry and Psychology of Maastricht UMC+

10.45-12.00 | Parallel sessions 1 and 2
Chair: Mayke Oosterloo, Neurologist, Maastricht UMC+
• Session 1: Basic Scientific, 3 selected presentations
Chair: Willeke van RoonAssistant Professor, Leiden University Medical Center, (LUMC) Department of Human Genetics
• Session 2: Clinical Scientific (Dutch), 3 selected presentations
Chair: Susanne de Bot, MD, Movement disorders, Leiden University Medical Center, (LUMC) Department Neurology

12.00-13.00 | Lunch break

13.00-13.05 | Introduction
Chair: Mayke Oosterloo; Neurologist, Maastricht UMC+

13.05-13.50 | Keynote lecture
• How the Huntington Gene Affects Brain Development (Pre-recorded) >
Peggy C. Nopoulos, Professor of Psychiatry, Department of Neurology, University of Iowa; Carver College of Medicine

13.50-14.10 | Break

14.15-15.30 | Parallel sessions 3 and 4
Chair: Mayke Oosterloo, Neurologist, Maastricht UMC+
• Session 3: Basic Scientific, 3 selected presentations
Chair: Harrie Kampinga, Professor, University Medical Center Groningen, (UMCG) Faculty of Medical Science
• Session 4: Clinical Scientific (Dutch), 3 selected presentations
Chair: David Linden, Professor Translational Neuroscience and Scientific Director of the School for Mental Health and Neuroscience (MHeNs) Maastricht University

15.30-16.00 | Awards
Chair: Rob Haselberg, Vereniging van Huntington (VvH)
• Best abstract Award
• Huntington Stimulation Grant Award (Presentation granted project)

16.00 | Closing
Mayke Oosterloo, Neurologist, Maastricht UMC+

Organizing committee

Mayke Oosterloo

Chair Dutch Huntington’s Disease Symposium
Neurologist, Maastricht University Medical Center. (MUMC+)
Read more >

Willeke van Roon-Mom

Assistant Professor,
Leiden University Medical Center, (LUMC) Department of Human Genetics
Read more >

Eric Reits

Professor,
Amsterdam University Medical Center, (AUMC) Department Medical Biology
Read more >

Harm Kampinga

Professor,
University Medical Center Groningen, (UMCG) Faculty of Medical Science
Read more >

David Linden

Professor Translational Neuroscience and Scientific Director of the School for Mental Health and Neuroscience (MHeNs) 
Read more >

Daisy Ramakers

Specialized in the field of movement disorders, Maastricht University Medical Center. (MUMC+) Department of Neurology.
Read more >

Rachel Jennekens

Maastricht University Medical Center. (MUMC+) Department of Neurology

Vivian Zwakenberg

Maastricht University Medical Center. (MUMC+) Department of Neurology

Marie-Thérèse Moers

School for Mental Health and Neuroscience (MHeNs) Maastricht University

The Huntington’s Disease Expertise Center Maastricht UMC+ strives to advance our understanding of Huntington’s Disease by performing research and the treatment and support of patients and their caregivers. We work together as a multidisciplinary team which consists of neurologists, neuropsychiatrists, psychologists, clinical and molecular geneticists and nurses. We perform mainly clinical research, participate in international trials and collaborate with researchers all over the world. The Huntington’s Disease Expertise Center Maastricht UMC+ is part of the Maastricht University Medical Centre+ (MUMC+) and aligned to the research school MHeNs (Mental Health and Neuroscience) which is part the Faculty of Health, Medicine and Life Sciences (FHML) of Maastricht University.